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Severity: Notice

Message: Trying to get property of non-object

Filename: controllers/VThunter.php

Line Number: 393

Backtrace:

File: /data/VThunterPlots/VThunter/application/controllers/VThunter.php
Line: 393
Function: _error_handler

File: /data/VThunterPlots/VThunter/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Trying to get property of non-object

Filename: controllers/VThunter.php

Line Number: 394

Backtrace:

File: /data/VThunterPlots/VThunter/application/controllers/VThunter.php
Line: 394
Function: _error_handler

File: /data/VThunterPlots/VThunter/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Trying to get property of non-object

Filename: controllers/VThunter.php

Line Number: 395

Backtrace:

File: /data/VThunterPlots/VThunter/application/controllers/VThunter.php
Line: 395
Function: _error_handler

File: /data/VThunterPlots/VThunter/index.php
Line: 315
Function: require_once

Summary: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] [NCBI]  [Proteinatlas]

Data set information

Featureplot of receptors

Expression: Ubiquitous expression in adrenal (RPKM 29.0), lung (RPKM 28.5) and 25 other tissues?